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Dimethocaine, also known as DMC or larocaine, is a compound with a stimulatory effect. This effect resembles that of cocaine, although dimethocaine appears to be less potent. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain.



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What is Dimethocaine ?
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Other name: Larocaine,
IUPAC name: 3-Diethylamino-2,2-dimethylpropyl-4-aminobenzoate
CAS No.: 94-15-5
Appearance: white to yellowish crystalline powder
Molecular Weight: 278.39
Molecular Formula: C16H26N2O2
Purity: 99% min.
Package: 1kg/foil bag or according to the customers requirements.
Storage: Store in a cool dry place and keep away from direct strong light.
Use: Local anesthetics. BUY DIMETHOCAINE ONLINE
Dimethocaine is a local anesthetic with stimulatory properties that is half the potency of cocaine. Dimethocaine is derivate  from cocaine, Dimethocaine is not a part of the organic alkaloid mix coming from a coca plant. Dimethocaine is very popular  research chemical, mainly used as local anesthetic, but also the stimulant qualities appeared to be shown immediately. First  of all it actually was explained that dimethocaine only has 10% of the potency because of cocaine, however customer  reviews have proven it’s not correct, effects are stronger than expected. The effects act like the ones from cocaine, emotional  state lift, euphoria and even stimulation, the results do not appear in a hurry like cocaine, on the other hand last longer.BUY DIMETHOCAINE ONLINE
  • Euphoria
  • Stimulation
  • Increased talkativeness
  • Mood lift
There are a limited number of reports about the drug’s effects. Most point to little activity or, at most, mild euphoria and mild stimulation.Buy Dimethocaine Online
Stimulation and euphoria offered by the drug is generally said to be weaker than what’s offered by cocaine or amphetamine.
The local anesthetic effect generally leads to numbness in the nasal region when taken intranasally.
Some users have experienced fatigue and slight mental impairment when the effects dissipate and even a lasting CNS depressant effect into the following day. However, the lack of experience reports makes it difficult to tell how common these after effects are. Buy Dimethocaine Online
Animal studies
It had a memory impairing effect in mice in a maze test. This was hypothesized in the paper to come from a dopamine mechanism. Lidocaine, which lacks similar dopaminergic activity, didn’t have the same response.
Greater locomotor activity and cocaine-like behavior effects were observed in mice.
Anxiogenic effects were seen at 10 mg/kg and 20 mg/kg in a maze test in mice.
Dimethocaine had some apparent dose-dependent antinociceptive effects in mice, including in writhing and hot-plate tests.

Chemistry & Pharmacology
Dimethocaine has a structure that’s closer to procaine, a drug that lacks psychoactive effects, than cocaine. A major difference is that it lacks a tropane ring.
It functions as a dopamine reuptake inhibitor. Possible actions at other sites haven’t been examined.
The drug was only slightly less potent than cocaine for displacing mazindol at the dopamine transporter (DAT).
DA reuptake inhibition potency appears to go in this order: Cocaine > Dimethocaine > Tetracaine > Procaine > Chloroprocaine.
Dimethocaine elevated dopamine in the nucleus accumbens in rats. It’s also been shown to elevate dopamine levels in the striatum.
EC500 (concentration for 500% basal level) in striatum
  • Cocaine: 15 uM
  • Dimethocaine: 57 uM
  • Procaine: 3.5 mM
Discriminative stimulus
It’s been found to be 2-3x less potent than cocaine in some drug discrimination studies.BUY DIMETHOCAINE ONLINE
Dimethocaine fully substituted for cocaine when rats were trained to discriminate cocaine from saline. It also fully substituted when rats were trained to discriminate cocaine from procaine, further indicating cocaine-like effects.
Investigation of its pharmacokinetics in rats showed extensive metabolism. The most important phase 1 steps were hydroxylation and deethylation. The most important phase 2 steps were acetylation and glucuronidation.
In vitro tests found roles for CYP1A2, CYP2C19, CYP2D6, and CYP3A4. N-acetylation was carried out by NAT2, but not NAT1.
Buy Dimethocaine online for sale
Buy Dimethocaine online for sale
Buy Dimethocaine Online was originally synthesized by the Hoffmann-La Roche company in 1930. It was sold under the market name larocaine. During the 1930s dimethocaine gained popularity in the US as a local anesthetic. Just like cocaine and procaine, it was used during surgery, primarily in dentistry, ophthalmology and otolaryngology. However, in the 1940s, it was removed from the market because of its psychoactive effects and risk of addiction. Nowadays dimethocaine is abused for these psychoactive effects. It is sold as a cocaine surrogate to circumvent legislation issues.

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